Helpful. View abstract. Nasal irrigation with Glycyrrhiza glabra extract for treatment of allergic rhinitis - A study of in vitro, in vivo and clinical trial. J Steroid Biochem Mol Biol 1994;49:81-5. Biofactors 2009;35(1):98-104. Endocrinol Jpn 1991;38(2):167-174. View abstract. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Effects of low-dose liquorice alone or in combination with hydrochlorothiazide on the plasma potassium in healthy volunteers. 83rd Annual Meeting of the Endocrine Society, June 20-23 2001;abstract P1-573. View abstract. Aging Clin Exp Res. Benefits of licorice root: Uses, side effects, and more Biol Pharm Bull. Side-effects of low-potassium levels can include lethargy and abnormal heart rhythms. Sheth, V. M. and Pandya, A. G. Melasma: a comprehensive update: part II. Ann Mtg Digestive Disease Week 1999 May. Exp.Mol.Med 12-31-2003;35(6):467-474. Eating Black Licorice Could Have Serious Side Effects - Eat This Not That MacKenzie, M. A., Hoefnagels, W. H., Jansen, R. W., Benraad, T. J., and Kloppenborg, P. W. The influence of glycyrrhetinic acid on plasma cortisol and cortisone in healthy young volunteers. Yamada, K., Kanba, S., Yagi, G., and Asai, M. Effectiveness of herbal medicine (shakuyaku-kanzo-to) for neuroleptic-induced hyperprolactinemia. Nahidi F, Zare E, Mojab F, Alavi-Majd H. Effects of licorice on relief and recurrence of menopausal hot flashes. Acharya SK, Dasarathy S, Tandon A, et al. Evaluation of contextual and demographic factors on licorice effects on reducing hot flashes in postmenopause women. View abstract. It contains kojic acid, witch hazel, and licorice extracts that reduce melanin production and exfoliate . N Engl J Med 1968;278(25):1381-1383. 17. Licorice Root: Benefits, Side Effects, Dosage, and More - Verywell Health View abstract. 2003;23(8):593-595. Pharmacotherapeutic effects of toki-shakuyaku-san on leukorrhagia in young women. View abstract. Liu J. Caubet-Kamar, N., Tubery, M., Garrouste, C., Lauque, D., and Kamar, N. Harmful effect of saline infusion in a patient with glycyrrhizic acid poisoning. View abstract. World J Gastroenterol 2-7-2006;12(5):760-764. Am J Chin Med 2005;33(5):747-758. Medicinal uses of licorice through the millennia: the good and plenty of it. View abstract. View abstract. View abstract. Natural treatment for PCOS - Nutritionist Dr. Cope Ou TT, Wu CH, Hsu JD, et al. Oh, G. S., Pae, H. O., Choi, B. M., Jeong, S., Oh, H., Oh, C. S., Rho, Y. D., Kim, D. H., Shin, M. K., and Chung, H. T. Inhibitory effects of the root cortex of Paeonia suffruticosa on interleukin-8 and macrophage chemoattractant protein-1 secretions in U937 cells. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Ito A, Hayashi N, Katayama K, and et al. Epilepsy Res 2021;176:106735. Treatment of duodenal ulcer with glycyrrhizinic-acid-reduced liquorice. Z Gastroenterol 2001;39(7):511-7. 2017;109:182-190. Neth J Med 2005;63:119-20. [Clinical observations on the treatment of the gestational hypertension syndrome with Angelica and Paeonia powder]. Kang, J. H., Park, Y. H., Choi, S. W., Yang, E. K., and Lee, W. J. Resveratrol derivatives potently induce apoptosis in human promyelocytic leukemia cells. Antimicrobial isoflavanoids and related substances from Glycyrrhiza glabra L. var. Can J Cardiol 2009;25(10):e357-e358. View abstract. Eur J Dermatol. View abstract. B. and Tang, T. Q. J Altern Complement Med 2000;6:557-9. Guo TL, Zhou XW. Effect of licorice on reduction of body fat mass in healthy subjects. Bardhan, K. D., Cumberland, D. C., Dixon, R. A., and Holdsworth, C. D. Clinical trial of deglycyrrhizinised liquorice in gastric ulcer. Menati L, Khaleghinezhad K, Tadayon M, Siahpoosh A. Anti Erection Pill. The yellow-brown thick-branched roots are used as medicine. 2003;84(1):85-89. Feng ZT, Xu J, He GC, Cai SJ, Li J, Mei ZG. A controlled trial of traditional Chinese herbal medicine in Chinese patients with recalcitrant atopic dermatitis. J Clin Pharm Ther 2001;26:271-8. Murck H, Lehr L, Hahn J, Braunisch MC, Jezova D, Zavorotnyy M. Adjunct Therapy With Glycyrrhiza Glabra Rapidly Improves Outcome in Depression-A Pilot Study to Support 11-Beta-Hydroxysteroid Dehydrogenase Type 2 Inhibition as a New Target. Pharmazie 2010;65(8):624-8. Peony: Uses, Side Effects, Dose, Health Benefits - EMedicineHealth Monitor your blood pressure closely. . Ma, X. F. [Experimental and clinical studies on the treatment of pulmonary heart disease and pulmonary hypertension with Paeonia lactiflora]. View abstract. But the potential side effects are real enough. therapy. Eur J Pharmacol 1981;72:219-25.. View abstract. 1991;78(1-2):1-6. View abstract. No negative side effects. View abstract. View abstract. A. 2007;30(10):1898-1904. Cancer Lett. View abstract. Chatterjee, N., Domoto-Reilly, K., Fecci, P. E., Schwamm, L. H., and Singhal, A. View abstract. J Pharmacol Exp Ther 2006;316:1369-77. Myopathies associated with red yeast rice and liquorice: spontaneous reports from the Italian Surveillance System of Natural Health Products. This versatile anti-inflammatory plant can benefit digestive issues, hormone health, and skin health as well as helping ease problems with menstruation and menopause. Gen Dent 2008;56(2):206-210. Phytother.Res. Licorice. Chen MF, Shimada F, Kato H, Yano S, Kanaoka M. Effect of glycyrrhizin on the pharmacokinetics of prednisolone following low dosage of prednisolone hemisuccinate. View abstract. View abstract. Sigurjonsdottir HA, Franzson L, Manhem K, et al. View abstract. Balakrishnan, V., Pillai, M. V., Raveendran, P. M., and Nair, C. S. Deglycyrrhizinated liquorice in the treatment of chronic duodenal ulcer. Licorice can be used orally with Peony to treat women with Polycystic Ovary Syndrom to increase fertility; it can also treat patients with abnormal Prolactin, muscle spasms, or to reduce the pain of cancer. Let's take a look at the forms, uses, and side effects of . The chemicals in licorice are thought to . October 15, 2021. Mol Nutr Food Res 2006;50(11):1080-1086. View abstract. NOW Supplements, Licorice Root (Glycyrrhiza glabra) 450 mg, Herbal Supplement, 100 Veg Capsules 208. View abstract. Li C, Wang ZB. The Benefits of Licorice Root for Women - Dr. Jolene Brighten Pharm Biol. I like herbal and fuit teas and a particular favourite of mine contains liquorice. Red Peony Root (Paeniae Rubra Radix) 8 g Myrrh (Myrrha) . Effects of chalcones isolated from licorice roots on leukotriene biosynthesis in human polymorphonuclear neutrophils. View abstract. Goto, F., Asama, Y., and Ogawa, K. Sho-saiko-to-ka-kikyo-sekko as an alternative treatment for chronic tonsillitis to avoid surgery. Adjuvant role of a new emollient cream in patients with palmar and/or plantar psoriasis: a pilot randomized open-label study. View abstract. WebMD does not provide medical advice, diagnosis or treatment. View abstract. View abstract. That's because licorice real black licorice, not the phony licorice-flavored stuff flavored with anise oil . About Dr.Cope. Deng, Y. Y., Chen, Y. P., Wang, L., Hu, Z., Jin, Y., Shen, L., Zhu, R., and Zhong, Y. View abstract. Peony (Paeonia spp). Licorice root contains glycyrrhizin, which can cause side effects when eaten in large amounts. Treatment of functional dyspepsia with a herbal preparation. Paeoniae Radix-containing herbal medicine for patients with restless legs syndrome: A systematic review and meta-analysis. A double-blind, randomized, placebo-controlled, multicenter trial. Ohta H, Ni JW, Matsumoto K, et al. J Pharmacobiodyn 1983;6:153-60. . Am J Chin Med 1996;24:165-8. Wilson, J. Morris DJ, Davis E, Latif SA. [Clinical observation on auxiliary treatment of hormone dependence dermatitis by shufeng liangxue decoction]. Z Kardiol 1991;80(6):389-391. Do White Peony and Licorice Help with Hirsutism Symptoms? Planta Med 1983;48(5):38-42. Shintani, S., Murase, H., Tsukagoshi, H., and Shiigai, T. Glycyrrhizin (licorice)-induced hypokalemic myopathy. Imtiaz, K. E. Sweet root, bitter pill: liquorice-induced hyperaldosteronism. is tatcha violet c brightening serum safe for pregnancy is tatcha violet c brightening serum safe for pregnancy The U.S. Food and Drug . Kumada T, et al. Unfortunately, there is not much scientific evidence around the use of Licorice in Hirsutism, and more studies are needed to prove if it's effective in hirsutism or not. View abstract. Cureus 2021;13(7):e16454. Armanini, D., Nacamulli, D., Francini-Pesenti, F., Battagin, G., Ragazzi, E., and Fiore, C. Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application. Lower potassium levels can cause those abnormal heart arrhythmias. Liquorice: Benefits, Dosage & Side Effects | Holland & Barrett Cureus 2020;12(11):e11656. Hypokalaemia and hypertension associated with use of liquorice flavoured chewing gum. Complement Ther Clin Pract. View abstract. View abstract. J Hepatol 1994;21:601-9. J Intern Med 1999;245:307-10. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. View abstract. Effects of glycyrrhizin on the pharmacokinetics of nobiletin in rats and its potential mechanism. Panduranga P, Al-Rawahi N. Licorice-induced severe hypokalemia with recurrent torsade de pointes. View abstract. The Potential Benefits and Side Effects of the White Peony Root. Antiviral Res 1989;11(5-6):255-261. J Clin Psychopharmacol 2008;28(3):264-370. Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double-Blinded, Placebo-Controlled, Randomized Clinical Trial. Some medications are moved in and out of cells by pumps. Apparent mineralcorticoid excess syndrome, an often forgotten or unrecognized cause of hypokalemia and hypertension: case report and appraisal of the pathophysiology. Wen Y, Tang Y, Li M, Lai Y. [Study on activating blood and eliminating stasis of total paeony glycoside(TPG)]. Arch Pharm Res 2002;25(3):293-299. Ito, M., Nakashima, H., Baba, M., Pauwels, R., De Clercq, E., Shigeta, S., and Yamamoto, N. Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV (HTLV- III/LAV)]. View abstract. Licorice might decrease how quickly the body breaks down methotrexate. Peony-glycyrrhiza decoction for antipsychotic-related hyperprolactinemia in women with schizophrenia: a randomized controlled trial. Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information. Caradonna, P., Gentiloni, N., Servidei, S., Perrone, G. A., Greco, A. V., and Russo, M. A. Takahara T, Watanabe A, Shiraki K. Effects of glycyrrhizin on hepatitis B surface antigen: a biochemical and morphological study. View abstract. Turpie AG, Runcie J, Thomson TJ. [13] A study in Japan compared the use of a . Licorice seems to change hormone levels in the body. View abstract. Neurology 2010;75(21):1939-1941. Sontia B, Mooney J, Gaudet L, Touyz RM. Kroes, B. H., Beukelman, C. J., van den Berg, A. J., Wolbink, G. J., van Dijk, H., and Labadie, R. P. Inhibition of human complement by beta-glycyrrhetinic acid. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Am J Chin Med 2001;29(3-4):459-467. J Clin Psychopharmacol 2016;36(6):572-9. Zhong Xi Yi Jie He Za Zhi 1990;10:101-2, 70. . Martin, M. D., Sherman, J., van der Ven, V., and Burgess, J. Ann Clin Biochem 2007;44(Pt 4):397-399. Phytother Res 2006;20(8):687-695. Hyodo T, Taira T, Kumakura M, et al. We describe a patient who suffered life-threatening hypokalemic paralysis caused by consumption of licorice in the form of a tea sweetener superimposed on long . Gomaa AA, Mohamed HS, Abd-Ellatief RB, Gomaa MA, Hammam DS. 2013 Nov;18(6):593-6. Effect of glycyrrhizin-containing toothpaste on dental plaque reduction and gingival health in humans. View abstract. Here are a few of them: . Lancet 2-10-1973;1(7798):294-295. All rights reserved. Oral Dis 2012;18(1):32-39. Paeoniflorin's. View abstract. View abstract. Read about Peony uses, side effects, health benefits, interactions, dose, warnings, and precautions. 2020. Practitioner 1973;210:820-3. Chien, C. F., Wu, Y. T., and Tsai, T. H. Biological analysis of herbal medicines used for the treatment of liver diseases. Ed. Effect of glycyrrhizin on viral replication and quasispecies in patients with type C chronic hepatitis. Eur Neurol 1992;32(1):44-51. View abstract. J Clin Endocrinol Metab 1990;70(6):1637-1643. Pak J Med Sci 2022;38(1):271-275. Fitoterapia 2006;77(7-8):613-614. View abstract. Chen, W. G. and Ba, Z. M. Prof. ZHANG Yi's experience in treating severe arrhythmia. Bronson Korean Panax Ginseng 1000 mg Supports Energy, Endurance & Vitality + Memory and Mental Performance, 120 Capsules. Lee, S., Lim, J. M., Jin, M. H., Park, H. K., Lee, E. J., Kang, S., Kim, Y. S., and Cho, W. G. Partially purified paeoniflorin exerts protective effects on UV-induced DNA damage and reduces facial wrinkles in human skin. View abstract. Side effects, toxicity, and interactions. 30. Another type of licorice, called DGL or deglycyrrhizinated licorice, does not seem to have the same side effects and is sometimes used to treat peptic ulcers, canker sores, and reflux (GERD). View abstract. Licorice use while Breastfeeding | Drugs.com Low doses of liquorice can induce hypertension encephalopathy. Crean, A. M., Abdel-Rahman, S. E., and Greenwood, J. P. A sweet tooth as the root cause of cardiac arrest. Further studies on the mechanism of the mineralocorticoid action of licorice in humans. Pharmacol Biochem Behav 1993;45:719-23. . Little is known about whether it's safe to use licorice root while breastfeeding. Patients received either bromocriptine 5 mg daily for 4 weeks followed by 4 weeks of 22.5 grams daily of the peony-licorice decoction (equivalent to 25 mg of glycyrrhetinic acid), or the same drugs in the reverse order. 2016 Oct;39:314-319. doi: 10.1016/j.intimp.2016.08.006. Rikknen K, Seckl JR, Heinonen K, Pyhl R, Feldt K, Jones A, Pesonen AK, Phillips DI, Lahti J, Jrvenp AL, Eriksson JG, Matthews KA, Strandberg TE, Kajantie E. Maternal prenatal licorice consumption alters hypothalamic-pituitary-adrenocortical axis function in children. Lee, S. M., Li, M. L., Tse, Y. C., Leung, S. C., Lee, M. M., Tsui, S. K., Fung, K. P., Lee, C. Y., and Waye, M. M. Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. The herb licorice may lower warfarin levels and can add to digoxin's effects. Horm.Res 1999;52(5):253-255. Front Psychiatry 2020;11:605949. May Harm Baby During Pregnancy. View abstract. Anesth Analg 2009;109(1):77-81. Int J Environ Res Public Health 2021;19(1):242. View abstract. Prospective study]. View abstract. 2014 Jun;23(3):189-92. J Hypertens 1985;3(1):19-23. Ital J Neurol Sci 1983;4(4):493-497. Select a condition to view a list of vitamins. Engqvist, A., von Feilitzen, F., Pyk, E., and Reichard, H. Double-blind trial of deglycyrrhizinated liquorice in gastric ulcer. Ned.Tijdschr Geneeskd. Phytotherapy Research 1997;11:207-210. van Gelderen, C. E., Bijlsma, J. G Ital Dermatol Venereol 2010;145(6):789-792. Fung AY, Look PC, Chong LY, et al. Medically reviewed by Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT By Kirsten Nunez on October 16, 2020. [Effect of Paeonia obovata 801 on metabolism of thromboxane B2 and arachidonic acid and on platelet aggregation in patients with coronary heart disease and cerebral thrombosis]. View abstract. View abstract. View abstract. Izv Akad Nauk Ser Biol 1997;2:235-7. . The author has contributed to research in topic(s): Rheum officinale. Peony and Licorice is a safe and gentle yet powerful formula that is famous for its ability to build blood and balance menstrual cycles. Licorice Consumption Causing Severe Hypokalemic Paralysis View abstract. Nephron 2002;90:240. Licorice Extract: Effects and Side Effects Xi'an Herb Bio View abstract. . A specific type of peony product, total glucosides of peony (TGP), has most often been used by adults in doses of 600 mg by mouth three times daily for up to 24 weeks. Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions. PEONY: Overview, Uses, Side Effects, Precautions, Interactions - WebMD Paeonia lactiflora Pall inhibits bladder cancer growth involving phosphorylation of Chk2 in vitro and in vivo. Zhong Yao Cai 2000;23:557-60. . View abstract. Best Underarm Whitening Creams For You 1. View abstract. Licorice or Mulethi, also known as "Sweetwood", is an effective and potent medicinal herb. Tacconi, P., Paribello, A., Cannas, A., and Marrosu, M. G. Carpal tunnel syndrome triggered by excessive licorice consumption. Kase Y, Saitoh K, Ishige A, et al. Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. J Pharmacobiodyn 1984;7:304-11. View abstract. Taking licorice along with estrogen might decrease the effects of estrogen. J Ethnopharmacol 2004;94:339-44. . Cisplatin is used to treat cancer. Radix Paeoniae Alba increases serum estrogen level and up-regulates estrogen receptor expression in uterus and vagina of immature/ovariectomized mice. J Assoc Physicians India 1978;26(9):811-814. Patel P, Aknouk M, Dawson A, et al. Paeoniflorin, a constituent of white peony root, has demonstrated inhibition of testosterone synthesis in vitro, without affecting estradiol synthesis.It reduces testosterone production by the ovaries but not the adrenal glands. View abstract. To learn more about how herbs are used to treat infertility, see this article. Chin J Integr Med 2022. View abstract. Liquorice supplements J Agric Food Chem 2012;60(36):9062-73. Westman EC, Guthrie GP. Taking licorice and loop diuretics together might make potassium levels drop too low. Dehours E, Vall B, Roug-Bugat ME, Florent B, Bounes V, Franchitto N. Suspected hypokalaemia following liquorice ingestion on board ship. For people who already have high blood pressure or heart or kidney disease, as little as 5 g/day can cause these side effects. Eur J Obstet Gynecol.Reprod Biol 2007;131(1):61-67. Tsuda T, Sugaya A, Ohguchi H, et al. Biol Pharm Bull 2007;30(11):2191-2195. Indian J Dent Res 2010;21(3):380-384. [Treatment of chronic hepatitis B. Chen LC, Chou MH, Lin MF, Yang LL. All rights reserved. Exp Ther Med 2016;11(3):1135-41. Peters, M. C., Tallman, J. Some medications are changed and broken down by the liver. 1986;6(12):714-6, 707. J Clin Hypertens (Greenwich) 2008;10:153-7. Luchon, L., Meyrier, A., and Paillard, F. [Hypokalemia without arterial hypertension by licorice poisoning]. Complement Ther Clin Pract. Bai, Y. S., Zhou, C. Y., and Wang, J. Q. View abstract. Cancer Lett 12-10-2001;174(1):17-24. Huang, W. W., Wang, M. Y., Shi, H. M., Peng, Y., Peng, C. S., Zhang, M., Li, Y., Lu, J., and Li, X. Kent UM, Aviram M, Rosenblat M, Hollenberg PF. View abstract. 2017 Sep;31(9):1330-1340. Contact Dermatitis 2008;59(1):52. Koster, M. and David, G. K. Reversible severe hypertension due to licorice ingestion. Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin. Guo, T. L. and Zhou, X. W. [Clinical observations on the treatment of the gestational hypertension syndrome with Angelica and Paeonia powder]. Kumada T, et al. Peony - Kaiser Permanente View abstract. Blood Press 2009;18:192-5. View abstract. World J Gastroenterol 2005;11:2124-9. . View abstract. Electronic Code of Federal Regulations. Steinberg, D., Sgan-Cohen, H. D., Stabholz, A., Pizanty, S., Segal, R., and Sela, M. N. The anticariogenic activity of glycyrrhizin: preliminary clinical trials. Akamatsu, H., Komura, J., Asada, Y., and Niwa, Y. Int Immunopharmacol. Beretta-Piccoli, C., Salvade, G., Crivelli, P. L., and Weidmann, P. Body-sodium and blood volume in a patient with licorice-induced hypertension. Licorice consumption and serum testosterone in healthy man. View abstract. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. View abstract. Armanini D, Lewicka S, Pratesi C, et al. 2011;25(2):312-313. For women taking oral contraceptives, there is a very small chance that this can counteract the effects of this medication. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. Biol Pharm Bull 2000;23:199-203.. View abstract. Licorice can cause serious side effects if you take too much of it or use it for too long. Iran J Pharm Res. View abstract. Hyodo T, Taira T, Kumakura M, et al. 2019;18(Suppl1):291-301. 2014 Jan;35(1):87-99. Am J Chin Med 2003;31:445-53. . View abstract. Armanini, D., Mattarello, M. J., Fiore, C., Bonanni, G., Scaroni, C., Sartorato, P., and Palermo, M. Licorice reduces serum testosterone in healthy women. Licorice Root: Benefits, Uses, Precautions, and Dosage - Healthline View abstract. OTHER NAME(S): Bai Shao, Chi Shao, Chinese Peony, Common Peony, C. Peony (Paeonia lactiflora) is an herb. 1. Too much black licorice, the federal agency says, can lead to "abnormal heart rhythms, as well as high blood pressure, edema (swelling), lethargy, and congestive heart failure." . Migraine is a type of headache. It's not suggested to take St. John's wort if you take blood thinners. View abstract. Int J Dermatol 1999;38:387-92 . A preliminary open trial on interferon stimulator (SNMC) derived from Glycyrrhiza glabra in the treatment of subacute hepatic failure. 2009;14(1):64-65. Early evidence suggests that taking 45 grams of a specific product containing peony and licorice (Peony-Glycyrrhiza Decoction, PGD) daily for 4 weeks reduces levels of a hormone called prolactin in women with high levels of prolactin, without affecting other hormone levels or mental symptoms. Wang H, Dong L, Qu F, et al. Therapeutic Research Faculty 2020. Anesth Analg. 1991;4(2):166-173. Wang W, Tian DD, Zheng B, et al. View abstract. View abstract. J Clin Psychopharmacol 2008;28(3):264-370. Therapeutic basis of glycyrrhizin on chronic hepatitis B. Antiviral Res 1996;30:171-7. Licorice might change how quickly the liver breaks down these medications. Clin Neurol Neurosurg 1993;95(1):35-37. Blood Press.